NEEDLE-FREE RECONSTITUTION

KOĀTE is administered intravenously (into a vein) after reconstitution. KOĀTE is supplied in powdered form and must be mixed with sterile diluent prior to administration.1

Every vial of KOĀTE comes with a Mix2Vial® transfer device, which allows for needle-free reconstitution.1

Ask your healthcare provider about the Mix2Vial® Practice Kit for step-by-step KOĀTE administration instructions and demonstration supplies so you can become comfortable with the reconstitution process.

 

ADMINISTRATION FAQs

Click on a question to see the answer. For more information about how to administer KOĀTE, including detailed administration instructions, please see the KOĀTE Full Prescribing Information.
How often is KOĀTE
administered?
 
 

Dose and frequency of infusions vary from person to person. Your doctor will determine the appropriate amount of KOĀTE for you or your child based on the specific clinical condition.1

How long does it take
to infuse KOĀTE?
 
 

The time it takes to infuse KOĀTE will depend on the dose and frequency of infusions that your doctor prescribes. Based on your comfort level, KOĀTE may be infused at a rate no faster than 10 mL per minute. This means that at the fastest rate, a 100 mL infusion of KOĀTE would take about 10 minutes, though it may take longer.1

Since there are no preservatives in the vial, KOĀTE should be used immediately or within 3 hours of reconstitution. Do not refrigerate KOĀTE after reconstitution.1

How soon after
reconstitution should
KOĀTE be administered?
 
 

Yes! You or a caregiver can be trained to administer KOĀTE in the comfort of your own home.

Can KOĀTE be
self-administered?
 
 
 

KOĀTE STORAGE AND HANDLING

PACKAGE
COLOR
IUs
PER Vial
DILUENT
SIZE
 
~250 IU
5 mL
 
~500 IU
5 mL
 
~1,000 IU
10 mL

KOĀTE is available in 3 single-use vial sizes. Note that the actual number of IUs may vary slightly from vial to vial. Always check the vial or carton label for the exact number of IUs in each vial.1

For your convenience, KOĀTE can be stored either at room temperature or refrigerated.1

  •  Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze KOĀTE.
  •  Store at room temperature (up to 25°C [77°F]) for up to 6 months.
  •  Store KOĀTE in its original packaging to protect it from light.
  •  Use reconstituted KOĀTE immediately or within 3 hours of reconstitution.

Always check the expiration date on the vial before using KOĀTE. Do not use KOĀTE after the expiration date.1

 

Reference: 1. KOATE [prescribing information]. Fort Lee, NJ. Kedrion Biopharma Inc. 2018.

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